Impact of Picamilon on the blood circulation system

Excessive impact of physical loads on the human body, especially at the initial stage of specialized training, has a disadaptive effect on the functional state of organs and systems, negatively affects the reliability of their work, and therefore leads to a decrease in athletic performance. Given that the sports result is predetermined to a large extent by the functional state of the cardiovascular system, an adaptive rearrangements indicator of the body autonomic functions, the cardiovascular system problem of effective readmission becomes obvious and urgent.
The study, consisting from 2 stages, was conducted under the doctor supervision with the parents’ informed written consent.
The study included 2 stages. At the first stage, the disadaptated swimmers (n = 29) were selected at the age of 10-12 years (I and II juvenile grades). At the second stage, by simple randomization, they are divided into 3 groups: 1st group-control (n = 8); The 2nd group (n = 9) took placebo, and the third group (n = 12) – picamilon.
Athletes of all groups after 4 weeks of training measured the height, weight, body surface area. Loads used in the training process were the same in structure, volume and intensity. After 20 minutes of rest after the warm-up, we determined ADs, ADd (mm by the NS method and calculated the ADP, SGD values. Hemodynamic indices were also recorded using the tetrapolar rheography method: inotropic cardiac function indices, systolic cardiac index (SSI), left ventricular contraction power, total cardiac output of the heart ironotrophic function. In the pumping function study of the heart, the circulation (IOC) and cardiac index (SI) minute volume were recorded. The total peripheral resistance of blood vessels to the blood flow was determined. The systemic circulation analysis was carried out using the statistical software package EXCEL 5.0a.
As a studies result it was found that after 4 weeks of training after 20 minutes of rest after intensive warm-up, the blood pressure parameters in swimmers of the 1st and 2nd groups did not differ significantly.
In the third swimmers group, who took picamilon as a recovery means, ADS was higher by 8.1% (p <0.01 and p <0.01), ADD – by 6.6% and 6.6%, ADP – 11.7% and 12.4%, and SRS – 7.0% (p> 0.05) and 6.8% (p> 0.05) with respect to control and “placebo” respectively, which could be evidence of activation sympathetic-adrenal system, which takes part in the formation of athletes’ adaptation to physical exertion.
It is known that, when adapting to muscular work, the heart rate can vary differently: relatively small cardiovascular system values ​​may be accompanied by an increase in heart rate, and higher CRM values – low or slightly altered heart rate as a result of adapted organism to physical loads growth.

Final results:

1. The heart rate values in all groups didn’t differ significantly, but in comparison groups were lower than those presented in literature.
2. Picamilon increased the inotropic component activity without a significant increase in the chronotropic component of cardiac activity, provided a more effective and economical way of adapting the swimmers cardiovascular system to physical activity.
3. The optimal pumping function level of the heart of disadaptated swimmers taking picamilon for the re-adaptation purpose was provided due to inotropic component of cardiac activity, cardiac output and myocardial contractility.
4. A significant contribution to maintaining the optimal blood pressure level was also made by the left ventricular capacity.
5. Between the peripheral vessels resistance, on the one hand, and the heart pumping function, myocardial contractility, on the other, negative interrelations have been found that contributed to maintaining the systemic blood pressure stability.
To be sure, without changing the heart rate, picamilon contributed to the optimal prerequisites creation for the re-adaptation of disadaptized swimmers and increase their efficiency.

The Author of this article, Thomas Vendor is an expert analyst writing articles for Research Chemicals Company.

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